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Even though different RCDs are considered individual and independent cell death modes for classification purposes, interconnectivity and extensive crosstalk on the basis of the shared molecular signaling network, redundancy, feedback, and backup function are well documented [10]

As a gram-negative pathobiont, Escherichia-Shigella can increase the intestinal load of LPS, thereby engaging in TLR4-dependent innate sensing and downstream NF-B programs